Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative m

The fibrillation process of the islet amyloid polypeptide (IAPP) and its fragment (IAPP((20-29))) was studied by means of Thioflavin T (ThT) fluorescence and transmission electron microscopy in the absence and presence of N-isopropylacrylamide:N-tert-butylacrylamide (NiPAM:BAM) copolymeric nanoparticles. The process was found to be strongly affected by the presence of the nanoparticles, which reta

Hydrophobic fumed silica dispersions in organic monomers were explored as a pore-forming system in polymer synthesis. The method developed provides a simple and effective way of controlling the pore size in highly cross-linked polymers. Fumed silica suspensions in divinylbenzene were polymerized with subsequent etching of the silica particles, therefore creating the porosity in the polymer. The re

Pericytes are located on the abluminal side of endothelial cells lining the microvasculature in all organs. They have been identified as multipotent progenitor cells in several tissues of the body including the human brain. New evidence suggests that pericytes contribute to tissue repair, but their role in the injured brain is largely unknown. Here, we investigate the role of pericytes in ischemic

Fondaparinux was associated with reduced major bleeding events and improved survival compared with low-molecular-weight heparin (LMWH) in a large randomized clinical trial involving patients with non-ST-segment elevation myocardial infarction (NSTEMI). Large-scale experience of the use of fondaparinux vs LMWH in a nontrial setting is lacking.

Acquired hemophilia A (AHA) is an autoimmune disease caused by an autoantibody to factor VIII. Patients are at risk of severe and fatal hemorrhage until the inhibitor is eradicated, and guidelines recommend immunosuppression as soon as the diagnosis has been made. The optimal immunosuppressive regimen is unclear; therefore, data from 331 patients entered into the prospective EACH2 registry were an

We have investigated the apparatus suspending the crystalline lens in the eyes of basal vertebrates. Data are presented for Holocephali (Chondrichthyes) and the actinopterygians Polypteriformes, Polyodontidae (Acipenseriformes), Lepisosteiformes, Amiiformes, and one teleost species, the banded archerfish (Toxotes jaculatrix). We also studied the optical properties of the lens in Polypteriformes, L

Over the last decades, many liberal democracies have experienced a tension between the education system’s expressed requirement to foster citizenship norms and the liberal (sub-) ideal of norm neutrality. This dilemma has been accentuated by, on the one hand, increased ethnical and cultural diversity, and, on the other hand, liberalization of society in general and the schooling system in particul

In the study of motor systems it is often necessary to track the movements of an experimental animal in great detail to allow for interpretation of recorded brain signals corresponding to different control signals. This task becomes increasingly difficult when analyzing complex compound movements in freely moving animals. One example of a complex motor behavior that can be studied in rodents is th

We present some general estimates of the scattered electromagnetic fields for a general bounded scattering domain Ω in the anisotropic materials setting. In particular, it is shown that the inline image - norm and sup norm of the scattered field in an arbitrary finite exterior domain Ωs is bounded by the H(curl,Ω) norm of the incident field. Moreover, several estimates of the traces of the scatter

Owing to the heterogeneity in the clinical phenotype of haemophilia A and B, it is now recognized that disease severity (based on factor VIII/IX activity) may no longer be the most appropriate guide for treatment and that a 'one-size-fits-all' approach is unlikely to achieve optimal therapy. Based on the present literature and consensus views of a group of experts in the field, this article highli

Large-scale multi-species data on population changes of alpine or arctic species are largely lacking. At the same time, climate change has been argued to cause poleward and uphill range shifts and the concomitant predicted loss of habitat may have drastic effects on alpine and arctic species. Here we present a multi-national bird indicator for the Fennoscandian mountain range in northern Europe (F

Two new compounds, [(C4H9)(4)P](2)[Cu5I7], and [(C4H9)(4) P](2)[Cu5I7]center dot CH3COCH2OH were synthesized by solvolysis and their crystal structures were solved. The first compound is disordered, but the solvate represents the first example of a fully ordered [Cu5I7](2-) cluster. It displays a molecular symmetry very close to C-2. Both compounds crystallize in space group P2(1)/c. (C) 2010 Else

Dug trenches in sediment-cored drumlins on the Småland peneplain, southern Sweden, occurring intermixed with rock-cored drumlins, revealed sedimentary successions and facies suggesting that the core sediments were primarily deposited proglacially, both in glaciolacustrine settings as delta-front and more distal deeper-water sediments, and as glaciofluvial braidplain sediments. From the relationshi

We present triethylboron (TEB) as a single-source precursor for chemical vapor deposition (CVD) of BxC thin films and study its gas phase chemistry under CVD conditions by quantum chemical calculations. A comprehensive thermochemical catalogue for the species of the gas phase chemistry of TEB is examined and found to be dominated by beta-hydride eliminations of C2H4 to yield BH3. A complementary b

Until the late 1990s researcher described a new strategy and organization for MNCs. The new MNC was omnipotent in character, striving for many new competitive advantages. This paper reviews the literature and synthesizes the ideas behind this Omnipotent MNC. General themes and key organizational characteristics are identified. A survey among large Swedish companies illustrate that many of the iden

A search is presented for microscopic black holes in a like-sign dimuon final state in proton-proton collisions at root s = 8 TeV. The data were collected with the ATLAS detector at the Large Hadron Collider in 2012 and correspond to an integrated luminosity of 20.3 fb(-1). Using a high track multiplicity requirement, 0.6 +/- 0.2 background events from Standard Model processes are predicted and no

Purpose This study seeks to investigate the long-term public health burden of Hodgkin lymphoma (HL) in terms of work loss following contemporary treatment protocols and associations with established treatment complications and lymphoma relapse. Methods We identified 1,989 Swedish HL patients (1,082 with clinical information) aged 18-60 (median 33) years at diagnosis 1992-2009, and matched 1:4 to p