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Substantial underreporting of anastomotic leakage after anterior resection for rectal cancer in the Swedish Colorectal Cancer Registry

Background: The causes and effects of anastomotic leakage after anterior resection are difficult to study in small samples and have thus been evaluated using large population-based national registries. To assess the accuracy of such research, registries should be validated continuously. Material and methods: Patients who underwent anterior resection for rectal cancer during 2007–2013 in 15 differe

Involvement of chromatin remodeling genes and the Rho GTPases RhoB and CDC42 in ovarian clear cell carcinoma

Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events driving OCCC tumorigenesis beyond ARID1A, which is reportedly mutated in 30-50% of OCCCs. We aimed to further characterize OCCCs by combined global

Early prediction of autoimmune (type 1) diabetes

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In child

Drug abuse-associated mortality across the lifespan : a population-based longitudinal cohort and co-relative analysis

Purpose: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. Method: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Re

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies

Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623

Testing the workplace injury reporting thesis : a three-state analysis

The annual total economic costs of workplace-related fatalities, illness and injury in Australia are estimated to exceed $57 billion dollars. Because of these societal costs, much policy attention is given to the reduction in the number and severity of workplace accidents, and in attempting to isolate critical factors impacting on these. Using a unique data set of monthly claims observations in Au

THE REMOVAL OF β-LACTOGLOBULIN FROM STAINLESS STEEL SURFACES AT HIGH AND LOW TEMPERATURE AS INFLUENCED BY THE TYPE AND CONCENTRATION OF CLEANING AGENT

In the food industry, severe fouling of equipment surfaces is common and frequent cleaning is necessary. The aim of this work was to contribute to an understanding of the cleaning process. The adsorption of β-lactoglobulin (β-LG) onto stainless steel surfaces and its removal by detergent were followed at 24 and 82C using in situ ellipsometry. Soil removal using different concentrations of sodium h

Design of closely packed pattern reconfigurable antenna array for MIMO terminals

In this paper, a compact pattern reconfigurable dual-antenna array is designed at 2.65 GHz for MIMO terminal applications, such as laptops. Each antenna is composed of two layers, i.e., the monopole layer and the PIFA layer. By switching the PIN diodes on each layer, its radiation patterns can be varied between conical and boresight patterns. Two such identical antennas are placed side by side on

Wear mechanisms of uncoated and coated cemented carbide tools in machining lead-free silicon brass

Free-machining brass containing 2–3% of lead is a preferred industrial material as it shows excellent machinability where low cutting forces, short chips and reduced tool wear are attained. However this addition of lead, a highly toxic and hazardous material, leads to health and environmental issues. Alternative lead-free brasses are known for poor chip control and accelerated tool wear. The curre

Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge

Abstract: This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, b