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Cubosomes for ruthenium complex delivery: formulation and characterization

An amphiphilic ruthenium-based molecule (DOPURu) with potential antineoplastic activity has been synthesized, and its aggregation behavior in the presence of phospholipids has been investigated. A very rich variety of aggregates has been found, spanning from vesicles to cubic bicontinuous phases. Cubosomes here presented represent one of the first systems with potential use for medical therapy.

The Quadratic Utilization Upper Bound for Arbitrary Deadline Real-Time Tasks

In high throughput applications, such as in multimedia, it is preferable to fully utilize computing resources, even at the price of some (bounded) delay. However, in real-time systems, where the maximum admissible delay is modeled by a deadline, most of the theory is developed with the assumption of a task deadline smaller than or equal to the task period. The reason of this limitation is in the i

Transference of Vector-valued Multipliers on Weighted L-P-spaces

New transference results for Fourier multiplier operators defined by regulated symbols are presented. We prove restriction and extension of multipliers between weighted Lebesgue spaces with two different weights, which belong to a class more general than periodic weights, and two different exponents of integrability that can be below one. We also develop some ad-hoc methods that apply to weights d

Benefits of GIS Application in Hydrological Modeling: A Brief Summary

During recent years, Geographic Information Systems (GIS) as a powerful tool have had a tremendous impact on research techniques in the realm of geography and spatial analysis. The integrative ability of GIS to capture, store, manipulate, analyze, manage, and finally present all types of geographical spatial data, has drawn many attentions to it. Water Resources Engineering as a interdisciplinary

Trade-Offs Between Forest Protection and Wood Supply in Europe

Forest protection is one of the main measures to prevent loss of biological and landscape diversity. This study aimed to assess to what extent forests are currently protected and how felling restrictions affect the potential annual wood supply within 27 European Union member states, Norway, and Switzerland and to discuss trade-offs between intensified use of forest biomass and forest protection ef

Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.

Poly-3-d-hydroxybutyrate (PHB) is a promising biopolymer naturally produced by several bacterial species. In the present study, the robust baker's yeast Saccharomyces cerevisiae was engineered to produce PHB from xylose, the main pentose found in lignocellulosic biomass. The PHB pathway genes from the well-characterized PHB producer Cupriavidus necator were introduced in recombinant S. cerevisiae

Effects of increased physical activity and motor training on motor skills and self-esteem. An intervention study in school years 1 through 9

OBJECTIVE: The aim was to study effects on motor skills and self-esteem of an extension of the Swedish school subject Physical Education and Health (PEW and motor training during nine school years. DESIGN AND METHOD: An intervention group (n=161) had PEH and motor training five lessons (225 nun) and a matched control group (n=102) had regular PEH two lessons (90 min) per week. The method was hypot

Seasonality and farm/non-farm interactions in Western Kenya

This article considers the distributional consequences of seasonality by analysing the links between non-farm incomes, commercialisation within agriculture, and variations in consumption burdens and expenditures at the household level. The common focus in the literature on non-farm incomes as levellers of seasonality and sources of risk minimisation is complemented by perspectives which consider h

Prospective Longitudinal Study of Thromboelastography and Standard Hemostatic Laboratory Tests in Healthy Women During Normal Pregnancy

BACKGROUND: Hemostatic disorders are common in obstetric complications. Thromboelastography (TEG (R)) simultaneously measures coagulation and fibrinolysis within 10 to 20 minutes. Our primary aim in this prospective longitudinal study was to obtain knowledge about physiological changes in TEG (R) variables during normal pregnancy and 8 weeks postpartum. The secondary aims were to compare TEG (R) v

AC-186, a Selective Nonsteroidal Estrogen Receptor beta Agonist, Shows Gender Specific Neuroprotection in a Parkinson's Disease Rat Model

Drugs that selectively activate estrogen receptor beta (ER beta) are potentially safer than the nonselective estrogens currently used in hormonal replacement treatments that activate both ER beta and ER alpha. The selective ER beta agonist AC-186 was evaluated in a rat model of Parkinson's disease induced through bilateral 6-hydroxydopamine lesions of the substantia nigra. In this model, AC-186 pr

Evaluation of housing adaptation interventions: integrating the economic perspective into occupational therapy practice

Objective: The home environment is a key determinant of health, quality of life, and well-being. Given its relevance for such aspects, the scarcity of evaluations of housing adaptation (HA) interventions aimed at removing environmental barriers and accessibility problems in the homes of people with disabilities is surprising. This article aims to contribute to the development of strategies for eco

Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.

This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass

A Swedish Population-Based Multivariate Twin Study of Externalizing Disorders.

In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug abuse (DA), criminal behavior (CB) and alcohol use disorders (AUD). Multivariate tw