OBJECTIVE: Sepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinica

Combustion remains the primary process for energy supply in nowadays society. With the emerging of low-carbon fuels alongside traditional fossil fuels, the increased complexity of thermal-chemical conversion processes call for more accurate diagnostic tools. Compared to traditional offline measurement techniques which are often insufficient in providing precise information, advanced laser diagnost

Patients with non-obstructive hypertrophic cardiomyopathy (HCM) exhibit myocardial changes which may cause flow inefficiencies not detectable on echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D-flow cardiovascular magnetic resonance (CMR) can provide more sensitive measures of flow in non-obstructive HCM.Methods and resultsNinety

Ti (C, N) based cermet materials are predominantly used in continuous finishing applications of metal cutting due to their high hardness, excellent resistance to oxidation and high chemical stability. However, their application in interrupted cutting like milling are limited due to their brittle-like failure due to low fracture toughness. In this work, alternative binder systems such as Co-Ni and

Samhällsutmaningarna har stått högt på dagordningen för forskning och innovation i Norden sedan Lunddeklarationen 20091. De sociotekniska systemen som ger oss energi, mat, hälsa och mobilitet, är inte hållbara. Motiveringen till att använda offentliga medel för forskning och innovation förändras i enlighet med detta. Forskning- och innovationspolitik motiveras inte längre enbart av forskningens eg

Stödgrupper för barn som växer upp i familjer med psykisk ohälsa, skadligt bruk/beroende eller våld är en insats som erbjuds av socialtjänsten i många kommuner. Trots att stödgrupper ges på frivilliga grunder utan biståndsprövning, dvs ”lätt tillgängligt” (Prop.2024/25:89), är rekryteringen av barn en utmaning. Denna licentiatuppsats fördjupar kunskapen om de förhållanden och överväganden som påveIn Sweden, preventive support groups for children exposed to domestic violence, substance abuse or mental illness in the home are provided by child welfare services (CWS). Support groups for children are often accessible without assessment, available for families to access at their own request, without formal referral or opening a case file which is assumed to lower the threshold. A current approa

HIV drug resistance (HIVDR) presents a significant challenge to antiretroviral therapy (ART) success, particularly in resource-limited settings like Ethiopia. This cross-sectional study investigated viral suppression rates and resistance patterns among patients on second-line ART across 28 Ethiopian health facilities. Blood samples collected from 586 participants were analyzed to measure CD4 count

Character displacement theory predicts that closely-related co-occurring species should diverge in relevant traits to reduce costly interspecific interactions such as competition or hybridization. While many studies document character shifts in sympatry, few provide corresponding evidence that these shifts are driven by the costs of co-occurrence. Black-capped (Poecile atricapillus) and mountain c

A new focal plane detector system for the Berkeley Gas-filled Separator (BGS) was designed, constructed, and tested offline with various -decay and conversion-electron sources. The SuperHeavy RECoils (SHREC) detector comprises sets of double-sided silicon strip detectors arranged in an open-faced cuboid geometry. Alongside the detector upgrade new digital data acquisition electronics have been com

Buy Now, Pay Later loans (BNPL) are an increasingly popular way to finance small-ticket purchases. We provide new evidence on how BNPL influences regular bank credit markets, benefiting both lenders and borrowers through information production and learning. Using data from over one million unsecured bank loan applications from a bank that also provides BNPL services, we exploit the fact that BNPL enh

We study the coherent photoproduction of light vector mesons in Pb-Pb collisions in the framework of color dipole approach. We employ the Glauber–Gribov formalism supplemented by an effective suppression factor RG accounting for the gluon shadowing correction. We adjust the latter to reproduce the deep inelastic structure function F2 (E665) and ρ meson photoproduction (ALICE) data. We achieve a go

Background: There is a lack of studies on sarcoidosis among immigrants, which is of interest as there may be genetic and environmental characteristics affecting immigrants from certain countries. We aimed to study hazard ratios (HRs) of sarcoidosis in first- and second-generation immigrants, comparing them with native Swedes in the total adult Swedish population. Methods: We conducted a nationwide

Molecular oxygen (O2) is essential for life, and continuous effort has been made to understand its pathways in cellular respiration with all-atom (AA) molecular dynamics (MD) simulations of, e.g., membrane permeation or binding to proteins. To reach larger length scales with models, such as curved membranes in mitochondria or caveolae, coarse-grained (CG) simulations could be used at much lower co

Background: It is uncertain whether the risk of major congenital anomalies (mCAs) is increased in children of women with inflammatory bowel disease (IBD). Methods: We aimed to determine the risk of mCAs in a Swedish nationwide cohort of 13,131 singleton live births from 1997-2020 to women with IBD and 61,909 matched children to women without IBD from the general population. We additionally examine

Introduction: The association between increasing diagnosis rates of autism-related disorders (ASD-R) in Swedish regions and diagnosis rates of major depressive disorders (MDD) in adolescents remains unexplored. Methods: Following STROBE guidelines, this pre-registered (https://osf.io/duvq7) observational study, utilizing registry data from 2008 to 2022 across the 21 Swedish regions, employed a gen

The electronic and magnetic properties of the interface formed between graphene and the multiferroic van der Waals material CuCrP2S6 are studied using X-ray spectromicroscopy, accompanied by DFT calculations. These results demonstrate the free-standing character of slightly p-doped graphene, protecting the underlying materials from the environment, while preserving the Dirac cone for the graphene-