Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. This thesis aims to promote personalised treatment and optimised outcomes through a clinical and pharmacokinetic characterisation.

The deliberation that precedes or runs alongside the remaking of cities, buildings and landscapes seem almost by default to generate situations with unsatisfied stakehold-ers, neglected citizen groups or completely ignored voices. What does it mean to find, listen and respond to those concerned by alteration of built environments? Here, in this paper, citizen participation, its ideological and pol

Located in southernmost Sweden, Malmö is part of the quickly developing urban landscape that defnes that part of the country, and it is in close proximity to the Danish border. Like many other coastal and border regions around the globe, this Scandinavian region experiences continuous population profle changes related to migration and is also facing rising sea levels; these conditions demand renew

In this paper, a view will be given on the establishment of large scale science facilities in Lund, Sweden, recognizing some of the recent political changes of this region around the end of 20th century and start of the 21st. During this time the well-renowned social democratic welfare politics in Sweden gave way to a more pragmatic third way politics with clear marks of a neoliberalist housing ma

AimLong-term cognitive decline after out-of-hospital cardiac arrest (OHCA) is still poorly understood. This study describes long-term observer-reported cognitive decline among Danish OHCA survivors, including differences in years since the event, and investigates characteristics and self-reported outcomes associated with observer-reported cognitive decline.MethodsAdults who survived an OHCA from 2AimLong-term cognitive decline after out-of-hospital cardiac arrest (OHCA) is still poorly understood. This study describes long-term observer-reported cognitive decline among Danish OHCA survivors, including differences in years since the event, and investigates characteristics and self-reported outcomes associated with observer-reported cognitive decline.MethodsAdults who survived an OHCA from 2

Samtiden präglas av sociala mediers flöden med allt från kakrecept till konspirationsteorier, algoritmernas enorma makt och samtidigt osynlighet, och en framväxande generativ AI:s kapacitet att sprida lögner, påhittade bilder och videor. Kan källkritik, en metod som en gång utvecklats inom historievetenskapen, vara lösningen på de många utmaningar som samhället står inför? I boken Källkritik: männ

Background Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics, Background: Evidence-based medicine recognizes that clinical expertise gained through experience is essential to good medical practice. However, it is not known what beliefs clinicians hold about how personal clinical experience and scientific knowledge contribute to their clinical decision making and how those beliefs vary between professions, which themselves vary along relevant characteristics,

States have discretion what concrete measures to undertake to fulfil their primary positive obligations under the ECHR. If a violation of these obligations is found, states also have discretion how to execute the judgment to comply with their secondary obligations. Yet, when the Court reasons to reach a conclusion whether there has been a violation, it necessarily specifies possible concrete measu

Making money at the expense of planet Earth is an unfortunate practice that has strengthened over the years with dire consequences for the environment and human rights.Although several initiatives have been taken at different levels to counter this phenomenon, environmentally unfriendly activities continue to be among the most serious crimes and human rights violations, while the need to prevent t

Natural aerosol feedbacks are expected to become more important in the future, as anthropogenic aerosol emissions decrease due to air quality policy. One such feedback is initiated by the increase in biogenic volatile organic compound (BVOC) emissions with higher temperatures, leading to higher secondary organic aerosol (SOA) production and a cooling of the surface via impacts on cloud radiative p

We report a detailed density functional theory and molecular dynamics study of hydrogen bonding between trehalose and water, with a special emphasis on interactions in the amorphous solid state. For comparison, water-water interactions in water dimers and tetramers are evaluated using quantum calculations. The results show that the hydrogen bonding energy is dependent not only on the geometry (bon