OBJECTIVE: We report the preliminary baseline characteristics in the ongoing phase 3 evoke and evoke+ trials investigating the safety and efficacy of oral semaglutide for early AD.BACKGROUND: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), is approved for use in type 2 diabetes (T2D) or obesity.DESIGN/METHODS: evoke (NCT04777396) and evoke+ (NCT04777409) are multicenter, randomi

Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An increased transmission was noted also in many hospitals. We analyzed SARS-CoV-2 in room air of hospitalized Omicron infected patients and compared results with previous findings with pre-Delta variants to study if SARS-CoV-2 was more prevalent in patient rooms after the introduction of

Rättspsykiatrisk vård befinner sig mitt i ett spänningsfält med tre poler: straff, vård och samhällsskydd. Den som är föremål för rättspsykiatrisk vård är en lagöverträdare dömd för brott till en påföljd, en patient som är omhändertagen för psykiatrisk tvångsvård och en person som är frihets-berövad med hänvisning till att personen utgör en samhällsfara. Detta medför att det frihetsberövande och ö

Generative AI tools (GenAI) are increasingly used for academic tasks, including qualitative data analysis for the Scholarship of Teaching and Learning (SoTL). In our practice as academic developers, we are frequently asked for advice on whether this use for GenAI is reliable, valid, and ethical. Since this is a new field, we have not been able to answer this confidently based on published literatu

As a dominant representative of biobased construction materials, an increased use of timber bears potential to contribute to climate change mitigation. This work investigated public attitudes towards timber as a building material, particularly focussing on the perception of fire safety properties and associated risks. In past studies timber’s susceptibility to fire was often acknowledged by stakeh

Genome-wide analyses of various taxa have repeatedly shown that immune genes are important targets of positive selection. However, little is known about what factors determine which immune genes are under positive selection. To address this question, we here focus on the mammalian immune system and investigate the importance of gene function and other factors such as gene expression, protein-prote

Acinetobacter baumannii (A. baumannii) is an opportunistic, Gram-negative human pathogen, which is predominantly found in hospital patients. Its antimicrobial resistance is escalating, leading to less efficient treatments, and an increasing interest in identifying new therapeutic drugs. Metals as antimicrobials are vital in healthcare and agriculture, and copper-containing surfaces are known to re

Agriculture is pivotal in the global economy but is challenged by unsustainable practices that harm the environment and aggravate social inequalities, particularly in sub-Saharan Africa (SSA). Women, making up half the agricultural workforce, often do not benefit equitably from their labour due to systemic gender inequalities. Applying a Feminist Political Ecology (FPE) lens reveals the unequal ge

The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto

To reach the non-mobile majority, universities in many contexts, especially in the Global North, are investing in the internationalization of the curriculum at home (IoCaH); however, experience shows that top-down strategies are implemented differently across disciplines. It has been suggested that the role of academic disciplines, an under-investigated dimension, can explain this variation. Throu

This study employs asymmetric flow field-flow fractionation online coupled with small angle X-ray scattering at a synchrotron beamline, along with multiple downstream detectors, including multi-angle light scattering, dual wavelength UV and dRI. This setup enables size-resolved characterization of lipid nanoparticles, allowing for a detailed comparison between empty and cargo-loaded lipid nanopart

Intermediate crops (ICs) are grown on large areas in Sweden and elsewhere for their function as cover or catch crops and to increase soil fertility, and they are usually soil-incorporated. The aim of this study was to investigate if aboveground biomass from ICs can be a sustainable source of biofuel feedstock. For that, the biomass yield of fertilized and unfertilized ICs was studied in field expe

Mycotic left ventricular pseudoaneurysm (LVP) is an uncommon life-threatening condition, resulting from myocardial rupture contained by the pericardium or scar tissue. Myocardial infarction is the leading cause of LVP, followed by cardiac surgery, previous chest trauma and infections. We present a case of a 69-year-old woman who developed a relapsing post-infarction LVP arising from mid infero-sep

Aims: Increased common carotid artery (CCA) intima media thickness (cIMT) is a well-known risk factor for cardiovascular morbidity and mortality. cIMT thickening has been described in patients with repaired aortic coarctation (CoA), but data on mechanism and clinical relevance in this population are scarce. Our aim was to gain mechanistic insights into cIMT thickening of patients with repaired CoA

Två generationer spelmän med en samstämmig inställning till det muskaliskaarvet som ett mycket personligt och glädjefyllt uttryck, möts över rungandehardingfeletoner och bjuder på utforskande lekfullhet och driv. Mats med sin djupa förankring i den värmländska musiken är en trogen gäst i Ransäter, och även Guro har setts här förr. I år även med sitt band GKN5.

Objectives This study aims to investigate (1) the microbial community composition by work characteristics and (2) the association between microbial genera level and inflammatory markers among recycling workers. Methods In this cross-sectional study, inhalable dust was collected with personal samplers from 49 production (86 samples) and 10 administrative workers (15 samples). Four groups of micro-o

This article uses new quantitative data to systematically test established arguments concerning the origins of party strength in 11 West European countries between 1870 and 1939. Through time-series cross-sectional analyses and using a wide range of sources, I investigate the role of the development of parliamentarism, suffrage extension, civil society, and the adoption of proportional representat

The Development of Parliamentarism in Western Europe dataset. Includes coding of government resignations and government-termination-attempts and estimations of the development of parliamentarism in Austria, Belgium, Britain, Denmark, Finland, France, Germany, Italy, the Netherlands, Norway, and Sweden from the establishment of parliaments until 2022.