Objectives To re-evaluate cut-offs for disease activity states according to the Axial Spondyloarthritis Disease Activity Score (ASDAS), and study the impact of sex, age, calendar time, disease and symptom duration on ASDAS and ASDAS cut-offs in a large contemporary cohort. Methods Data from 2939 patients with axial spondyloarthritis (axSpA) starting their first tumour necrosis factor inhibitor in

Cataract surgery is the most commonly performed surgery worldwide. However, there is significant variation in practice both within and among countries. The European Registry of Quality Outcomes for Cataract and Refractive Surgery was established in 2007 to address this variation and improve the quality of care. Based on registry data from more than 500,000 surgeries, the registry developed the fir

In conventional tomographic reconstruction, the pre-processing step includes flat-field correction, where each sample projection on the detector is divided by a reference image taken without the sample. When using coherent X-rays as a probe, this approach overlooks the phase component of the illumination field (probe), leading to artifacts in phase-retrieved projection images, which are then propa

Modeling of riverine dissolved organic carbon (DOC) dynamics is of great importance for the global carbon budget. Impoundment interception changes the travel time of water and DOC from upslope contributing areas, exerting substantial influence on riverine DOC dynamics in the catchments with many impoundments. However, the impact of impoundment interception representation on riverine DOC modeling h

I tidigare forskning inom strategisk kommunikation har klimatförändringar undersökts utifrån ett rationellt sätt att kommunicera olika politiska, företagsmässiga eller vetenskapliga intressen. Dessa studier förhåller sig ofta till känslor som antingen psykologiska effekter av planerad kommunikation eller som redan existerande faktorer vilka påverkar förståelsen av frågan. I dessa studier anses denPrevious research has studied the strategic communication of climate change as a rational and purposeful means of communicating about climate change in accordance with political, corporate or scientific interests. These studies often consider emotions either as the psychological effects of planned communication, or as pre-existing attachments that influence an individual's understanding of the iss

Dams are vital for irrigation, power generation, and domestic water needs, but siltation poses a significant challenge, especially in areas prone to water erosion, potentially shortening a dam’s lifespan. The Ahmed El Hansali Dam in Morocco faces heightened siltation due to its upstream region being susceptible to erosion-prone rocks and high runoff. This study estimates the siltation at the dam f

Clustering samples based on similarity remains a significant challenge, especially when the goal is to accurately capture the underlying data clusters of complex arbitrary shapes. Existing density-based clustering techniques are known to be best suited for capturing arbitrarily shaped clusters. However, a key limitation of these methods is the difficulty in automatically finding the optimal set of

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of methylxanthines in preventing or treating intermittent hypoxemia or respiratory insufficiency in late preterm infants.

Clinical genetic laboratories often require a comprehensive analysis of chromosomal rearrangements/structural variants (SVs), from large events like translocations and inversions to supernumerary ring/marker chromosomes and small deletions or duplications. Understanding the complexity of these events and their clinical consequences requires pinpointing breakpoint junctions and resolving the deriva

Knock detection is critical for maintaining engine performance and preventing damage in spark-ignition engines. This study explores the use of ion current and knock indicators derived from a vibration sensor ((Formula presented.)) and ion current ((Formula presented.)) to improve knock detection accuracy. Traditional threshold-based methods rely on (Formula presented.), but they are susceptible to

De svenska utbildningsmyndigheterna står inför ett seglivat problem. Lärare har under många år uttryckt missnöje över alltmer utbredda och genomgripande krav på dokumentation. En hel del dokumentation stjäl tid som annars skulle kunna läggas på elevers lärande och att utveckla undervisningen, lyder klagomålen. Under de senaste 15 åren har olika svenska regeringar försökt åtgärda detta problem, menThe Swedish education authorities are up against a tenacious problem. Teachers have for years expressed dissatisfaction over increasingly prolific and pervasive demands for documentation that hijacks time that could have been invested in pupils’ learning. Over the past 15 years different Swedish governments have sought to remedy this problem but to no avail. The ‘burden of documentation’, as it is

Early organogenesis represents a key step in animal development, during which pluripotent cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell transcriptomes from mouse embryos between E8.5 and E9.5 in 6-h intervals and combined this new dataset with our previous atlas (E6.5-E8.5) to produce a densely sampled timecourse of >400,000 cells from early gastrulation to orga

In 1926, the Finnish physician Erik Adolf von Willebrand first described an inherited bleeding disorder with features that suggested that this disease was distinct from classic hemophilia and other bleeding disorders. The original observations were made by members of a large family (family S) living on the island of Föglö in the Åland archipelago in the Baltic Sea. The index case was a young girl,

We study the time complexity of computing the (min, + ) matrix product of two n× n integer matrices in terms of n and the number of monotone subsequences the rows of the first matrix and the columns of the second matrix can be decomposed into. In particular, we show that if each row of the first matrix can be decomposed into at most m1 monotone subsequences and each column of the second matrix can

We consider two continuous-time generalizations of conservative random walks introduced in Englander and Volkov (2022), an orthogonal and a spherically symmetrical one; the latter model is also known as random flights. For both models, we show the transience of the walks when d ≥ 2 and that the rate of direction changing follows a power law t-α, 0 < α ≤ 1, or the law (In t)-β where β ≥ 2.

Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary peptide nucleic acid (PNA) probes has been investigated. The pretargeting relies on s

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associat

The problem of equivalence in terms of multistability properties between gene regulatory network models of different dimensionality has been recently addressed by Schittler et al.(2013). The authors in that work proposed construction rules for a high-dimensional dynamical system, when given a low-dimensional dynamical system and the high-dimensional network structure. However, the proof therein wa

When assessing patients presenting with weakness to the emergency department, the initial focus is on determining whether patients are suffering from conditions where prompt treatment decreases morbidity and mortality. Diagnosis is based on an understanding of neuroanatomy and on pattern recognition. A structured history, combined with selected physical examinations and bedside tests, are used to