Mycobacterial ESX-1 may target mitochondria to modulate the immune response
Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis (Mtb). Infection occurs through inhalation of bacteria-containing droplets. After entry into the respiratory tract the bacteria mainly reside within macrophages in the lung by using different strategies to escape killing by the immune system. The attenuated Mycobacterium bovis strain Bacille Calmette