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Mouse hippocampal organotypic tissue cultures exposed to in vitro "ischemia" show selective and delayed CA1 damage that is aggravated by glucose

Oxygen and glucose deprivation (OGD) in cell cultures is generally studied in a medium, such as artificial cerebrospinal fluid (CSF), with an ion composition similar to that of the extracellular fluid of the normal brain (2 to 4 mmol/L K+, 2 to 3 mmol/L Ca2+; pH 7.4). Because the distribution of ions across cell membranes dramatically shifts during ischemia, the authors exposed mouse organotypic h

Vinegar dressing and cold storage of potatoes lowers postprandial glycaemic and insulinaemic responses in healthy subjects

Objective: To investigate the effects of cold storage and vinegar addition on glycaemic and insulinaemic responses to a potato meal in healthy subjects. Subjects and setting: A total of 13 healthy subjects volunteered for the study, and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, Sweden. Experimental design and test meals: The study included four meals; fresh

Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa

Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose

Neuropeptides and the regulation of islet function.

The pancreatic islets are richly innervated by autonomic nerves. The islet parasympathetic nerves emanate from intrapancreatic ganglia, which are controlled by preganglionic vagal nerves. The islet sympathetic nerves are postganglionic with the nerve cell bodies located in ganglia outside the pancreas. The sensory nerves originate from dorsal root ganglia near the spinal cord. Inside the islets, n

Propane ammoxidation on an Al-Sb-V-W-oxide catalyst. A mechanistic study using the TAP-2 reactor system

The reaction mechanism of propane ammoxidation was studied on an Al-Sb-V-W-oxide catalyst using a TAP-2 reactor system. Analyses of the responses from both high-speed pulse transients with reactants and TPD experiments were performed. Since the ammoxidation process with three reactants proceeds from propane to acrylonitrile over propylene as an intermediate, the experiments comprised oxidation of

The EUROBALL neutron wall - design and performance tests of neutron detectors

The mechanical design of the EUROBALL neutron wall and neutron detectors, and their performance measured with a Cm-246,Cm-248 fission source are described. The array consists of 15 pseudohexaconical detector units subdivided into three, 149 mm high, hermetically separated segments and a smaller central pentagonal unit subdivided into five segments. The detectors are filled with Bicron BC501A liqui

Quantum interference between multi photon absorption pathways in organic solid

We demonstrate spatial interference fringe pattern by simultaneous one- and three-photon absorption of UV and near-IR femitosecond pulses in thin film organic solid at room temperature. We use organic dendrimers that are specially designed to have strong fluorescence and very large three-photon absorption cross-section. High fringe visibility allows the quantum interference to be observed by eye.

Improved preparation technique of cervical carcinoma for flow cytometric DNA analysis with tissue disintegration in hydrochloric acid

An one-step procedure using a nuclear isolation medium containing propidium iodide has been found to be a suitable preparation technique for flow cytometric DNA analysis in breast cancer samples. In the case of cervical squamous carcinoma, a pretreatment with HCl seems to be a methodological improvement. One advantage with the HCl modification is that some "false" near-diploid cell populations are

Pain following Surgery: Management, Outcome, and Prediction

Despite advances in the treatment of postoperative pain, nearly 30% of patients experience moderate to severe pain following major surgery. The present thesis includes four studies intended to evaluate important aspects of postoperative pain. In studies I and II, patient-controlled epidural analgesia (PCEA, n = 1,670), using local anesthetics and morphine, was associated with significantly lower

Free N-acetylneuraminic acid in tissues in Salla disease and the enzymes involved in its metabolism

Salla disease is a lysosomal storage disorder of unknown etiology, characterized biochemically by increased urinary excretion of N-acetylneuraminic acid. This compound has now been shown to occur in abnormally large amounts in liver and cultured skin fibroblasts from these patients. Quantification of N-acetylneuraminic acid was performed using a new gas-chromatography/mass spectrometric single-ion

How to predict nephropathy in type 1 diabetic patients - Routine data or provocation by exercise testing?

Objective: Do exaggerated increases in blood pressure and albuminuria during exercise occur earlier than microalbuminuria and which type of test is most predictive of diabetic nephropathy? Material and Methods: A total of 33 insulin-dependent normoalbuminuric men (mean duration of diabetes 14 years; mean age 28 years) and 34 age-matched apparently healthy control subjects were studied. Urinary alb

Smoking as a determinant of the geographical pattern of cardiac events among women in an urban population

Background: Smoking is the major risk factor for cardiac events in younger women and is most common in groups with the least favourable socioeconomic circumstances. Objective: To assess to what extent geographical differences in the female incidence of myocardial infarction in the city of Malmo in Sweden can be accounted for by smoking and to what extent intra-urban variances of smoking are relate

Channel Related Optimization of Wireless Communication Systems

This thesis deals with different optimization problems in the design of wireless communication systems. It is mainly directed to the design of systems based on multicarrier techniques and orthogonal frequency division multiplex, OFDM, but some of the problems apply to single carrier systems as well. The influence of different pilot patterns is analyzed when pilot symbol assisted modulation, PSAM,

Communication in Games and Decision Making under Risk

Popular Abstract in Swedish Avhandlingen är indelad i två delar. I den första delen studeras hur kommunikation påverkar utfall i strategiska situationer, så kallade spel. Den andra delen studerar individers riskpreferenser. Metodologiskt förlitar sig avhandlingen till största delen på ekonomiska experiment. I kapitel 2 till 4, som är författade tillsammans med Ola Andersson, studeras effekterna aThis thesis is divided into two distinct parts. The first part studies communication in games and the second part investigates individual decision making under risk. Chapters 2 – 4, co-authored with Ola Andersson, investigate communication and renegotiation in dynamic games. In Chapter 2, Bertrand supergames with non-binding communication are used to study price formation and stability of collus