Impactful applications such as materials discovery, hardware design, neural architecture search, or portfolio optimization require optimizing high-dimensional black-box functions with mixed and combinatorial input spaces. While Bayesian optimization has recently made significant progress in solving such problems, an in-depth analysis reveals that the current state-of-the-art methods are not reliab

Many diatoms form long chains and the distribution of chain lengths within a species depends on several environmental factors, among them grazing risk. Larger grazers, such as copepods, efficiently handle and ingest even very long chains but are less efficient with individual cells, whereas most smaller grazers are unable to feed on chains exceeding a few cells in length. Copepod cues make several

Scheduling between mates in species with long-term pair bonds can be essential for positive fitness. The annual cycle in photoperiod is the primary environmental cue used by many animals to synchronize behavior and physiology among members of a population, and animals that migrate must have similar annual schedules to ensure successful breeding. However, we know little about whether members of mat

IntroductionOccupational balance has been investigated in different populations but less in stroke survivors. Previous studies have focussed on occupational balance among stroke survivors of working age (15–64 years of age), showing they did not perceive they had occupational balance. There is, therefore, a lack of knowledge of how older stroke survivors perceive their occupational balance. The aiIntroductionOccupational balance has been investigated in different populations but less in stroke survivors. Previous studies have focussed on occupational balance among stroke survivors of working age (15–64 years of age), showing they did not perceive they had occupational balance. There is, therefore, a lack of knowledge of how older stroke survivors perceive their occupational balance. The ai

The present study collected a wide range of experimental data samples, including 855 records from various types of cylindrical weirs under diverse hydraulic conditions, setting the stage for an in-depth analysis for modeling of discharge coefficient. For this purpose, the prediction capability of four kernel-based methods (SVM, GPR, KELM, and KRR) and four neural network-based methods (FFBP, CFBP,

The Storage Location Assignment Problem (SLAP) is of central importance in warehouse operations. An important research challenge lies in generalizing the SLAP such that it is not tied to certain order-picking methodologies, constraints, or warehouse layouts. We propose the OBP-based SLAP, where the quality of a location assignment is obtained by optimizing an Order Batching Problem (OBP). For the

Background: Blood typing is essential for safe transfusions and is performed serologically or genetically. Genotyping predominantly focuses on coding regions, but non-coding variants may affect gene regulation, as demonstrated in the ABO, FY and XG systems. To uncover regulatory loci, we expanded a recently developed bioinformatics pipeline for discovery of non-coding variants by including additio

The implementation of deep learning algorithms has brought new perspectives to plankton ecology. Emerging as an alternative approach to established methods, deep learning offers objective schemes to investigate plankton organisms in diverse environments. We provide an overview of deep-learning-based methods including detection and classification of phytoplankton and zooplankton images, foraging an

This article looks at the photographic parts of the archive of racial biology in Uppsala, Sweden. This material is approached both through works by Swedish Sámi artist Katarina Pirak Sikku as well as through close engagements with the archive itself and its historical circumstances. In the article, the focus is on affective and emotional relations to the archival photographs and the events of thei

Background: Heart failure (HF) has a high prevalence in an elderly population and leads to a substantial hospitalization and mortality. The objective of this study was to investigate factors that affect hospitalization and mortality in an elderly population. Methods: A retrospective observational study was conducted of HF patients aged 76–95 years residing in Region Halland, Sweden. Between 2013 a

Background: Cognitive impairment is common in Parkinson’s disease (PD), but care needs and resource use for those with significant cognitive impairment are not well established. Methods: 675 participants with PD from the international Care of Late-Stage Parkinsonism (CLaSP) study were grouped into those without (n = 333, 49%) and with cognitive impairment (MMSE < 24/30 or diagnosis of dementia or

Older adults have multiple medical and social care needs, requiring a shift toward an integrated person-centered model of care. Our objective was to describe and summarize Swedish experiences of integrated person-centered care by reviewing studies published between 2000 and 2023, and to identify the main challenges and scientific gaps through expert discussions. Seventy-three publications were ide

There are substantial concerns about impaired honey bee health and colony losses due to several poorly understood factors. We used MALDI profiling (MALDI BeeTyping®) analysis to investigate how some environmental and management factors under field conditions across Europe affected the honey bee haemolymph peptidome (all peptides in the circulatory fluid), as a profile of molecular markers represen

Adolescent mental health is difficult to capture in categories such as depression or specific anxiety disorders. An alternative is to approach psychiatric symptoms as causal networks, potentially revealing feedback loops that maintain a pathological state. One approach to creating such networks, implemented in the PECAN methodology, is to ask adolescents about their perceptions of the causes to th

The aim of this study is to investigate the association between self-perceived voice problems and social participation among older adults (65-80 years). A complementary aim was to investigate the association between self-perceived voice problems and physical activity. Method Participants were recruited through social media and asked to complete an online questionnaire. In total, 152 individuals we

Dip-and-pull ambient pressure X-ray photoelectron spectroscopy (AP-XPS) holds promise to uncover elementary processes of (photo)electrochemistry. We show, however, that the sample for such experiments should preferably be nonporous and the potential on the surface homogeneous. We carried out dip-and-pull AP-XPS experiments on a hematite thin film sample under the photoelectrochemical oxygen evolut

This article theoretically investigates the conditions that empower actors (entrepreneurs and intrapreneurs) to pursue combinatorial innovation processes, and thereby contribute to transformative activities with a high degree of novelty and complexity. We argue that the possibility for combinatorial innovation depends on agents’ time perspective and combinatorial capabilities. We elaborate why ins

Background: Continuous advancements in interventional and diagnostic radiological techniques are mandatory to meet the increasing demands of patients and health care professionals. This thesis aims to contribute to the development of more effective interventional and diagnostic radiological methods for pelvic diseases. Ultimately, these advancements can lead to improved patient outcomes, optimised