Activating Notch1 mutations have been reported in human T-line-age acute lymphoblastic leukemia (T-ALL) and lymphomas from genetically modified mice. We report that Notch1 is a prevalent and major mutational target in chemically induced mouse lymphoma. The regions of the gene that are frequently mutated are the heterodimerization domain and the N-terminal ligand-binding region, important for prote

En översättning av en essä av Andrej Losjak, publicerad i Gläntas temanummer med översättningar av utvalda texter ur den ryska kulturtidskriften Coltas arkiv.

The article gives an insight into the dramaturgical tools that are applied in the site specific and participatory performance Island, that was performed in Hrísey, an island north off the coast of Iceland in 2020. The project is a part of the artistic PhD research How Little is Enough? Sustainable Methods of Performance for Transformative Encounters, at Malmö Theatre Academy, University of Lund, t

Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters, which are part of the subunits of the respiratory chain. The mitochondrial late ISC pathway mediates the formation of these clusters from simpler [2Fe-2S] molecules and transfers them to client proteins. Here, we characterized the late ISC pathway in one of the simplest mitochondria, mitosomes, of the anae

Det råder bostadsbrist i Sverige. Samtidigt har vi Västeuropas största bostadsyta per capita. Vi hävdar att det är både onödigt och ohållbart att slentrianmässigt se nybyggnation som den enda lösningen. Det finns ytterligare en: att använda det som redan är byggt, genom att dela och omfördela ytor.

Arguments for context-sensitivity are often based on judgments about the truth values of sentences: a sentence seems true in one context and false in another, so it is argued that the truth conditions of the sentence shift between these contexts. Such arguments rely on the assumption that our judgments reflect the actual truth values of sentences in context. Here, I present a non-semantic explanat

BACKGROUND: Low level of physical activity is a risk factor for new cardiac events in out-of-hospital cardiac arrest (OHCA) survivors. Physical activity can be assessed by self-reporting or objectively by accelerometery.AIM: To investigate the agreement between self-reported and objectively assessed physical activity among OHCA survivors HYPOTHESIS: Self-reported levels of physical activity will s

Background and aims: Previous studies of primarily Western populations have consistently documented a lower risk of type 2 diabetes (T2D) among people with a higher yogurt intake, but an inconsistent association with milk intake. However, little is known about the association between dairy intake and risk of T2D among Chinese adults who consume considerably less dairy (mainly milk and yogurt) com

The association between the consumption of dairy products and risk of CVD has been inconsistent. There is a lack of studies in populations with high intakes of dairy products. We aimed to examine the association between intake of dairy products and risk of incident major adverse coronary events and stroke in the Swedish Malmö Diet and Cancer cohort study. We included 26 190 participants without pr

Carbohydrate quality might be more important than quantity to reduce type 2 diabetes (T2D) risk. Various metrics of carbohydrate quality exist; however, their associations with T2D have only been studied to a limited extent. Consequently, the aim was to investigate the association between four different pre-defined carbohydrate quality indices, with various amounts of fiber (≥1 g) and free sugar (

When developing tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute geometrically valid morphometry measures. In practice, accurate cortical segmentation is challenged by image artifacts and the highly convoluted anatomy of the cortex itself. To address this, we propose a novel deep learning-based cortical segmentat

Background: The work for Swedish home care workers is challenging with a variety of support and healthcare tasks for home care recipients. The aim of our study is to investigate how these tasks relate to workload and health-related quality of life among home care workers in Sweden. We also explore staff preferences concerning work distribution. Methods: A cross-sectional study was conducted in 16

Background: Dysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA). Citrullination is induced by immune cell-derived peptidyl-Arg deiminases (PADs), which are overactivated in the inflamed synovium. We characterized the effect of PAD2- and PAD4-induced citrullination on the abi