Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water

We examine the relationship between occupational automation probabilities and employment dynamics over nearly two decades. We show that employment and wage shares of occupations with a higher automation risk have declined in Sweden over the period 1996-2013. This has occurred both at the aggregate private business sector but also within firms, where the wage share changes have been larger than the

AIMS/HYPOTHESIS: Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity

AIM: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metf

Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD‐L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab‐paclitaxel. How

Our society is moving towards renewable resources, where biomass, rich incarbohydrates, is producing chemicals and fuel. However, there are severallimitations when it comes to valorisation of the carbohydrates from renewablebiomass. One major hurdle is the over-functional nature of carbohydrates, making them difficult to process by conventional chemistry. Carbohydrate activeenzymes can help overco

Software developers use collection data structures extensively andare often faced with the task of picking which collection to use.Choosing an inappropriate collection can have major negativeimpact on runtime performance. However, choosing the right collectioncan be difficult since developers are faced with many possibilities,which often appear functionally equivalent. One approachto assist develo

Superconductor-ferromagnetic heterostructures have been suggested as one of the most promising alternatives of realizing odd-frequency superconductivity. In this work we consider the limit of shrinking the ferromagnetic region to the limit of a single impurity embedded in a conventional superconductor, which gives rise to localized Yu-Shiba-Rusinov (YSR) bound states with energies inside the super

Industrial Control Systems (ICS) are becoming more and more connected. Whileconnecting systems increases flexibility productivity in ICS, it also introduces risks and security vulnerabilities. Media have reported several cyberattacks against ICS, and security is a top priority in the next generation of ICS. High availability requirements and severe consequences of cyber-attacks make securing ICS a

As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a genetic cause of thiopurine toxicity, and NUDT15-informed preemptive dose reduction was quickly adopted in clinical settings. To exhaustively identify pha

Metazoans must develop from zygotes to feeding organisms. In doing so, developing offspring consume up to 60% of the energy provided by their parent. The cost of development depends on two rates: metabolic rate, which determines the rate that energy is used; and developmental rate, which determines the length of the developmental period. Both development and metabolism are highly temperature-depen

Conventional wisdom pretends that currency devaluations contributed to the Great Depression of the 1930s. This paper examines the impact of nominal exchange rates on foreign trade of 14 industrialized countries 1929-1939. If the idea of competitive devaluation holds, one should expect an increase in exports, along with a decline in imports, to trading partners against which the exchange rate depre

Physical activity is associated with lower risks of developing dementia, Parkinson’s disease (PD) and depression. Furthermore, being physically active prior to brain ischemia appears to help the recovery process. However, previous studies do not differentiate between the two most common forms of dementia, Alzheimer’s disease (AD) and vascular dementia (VaD), when it comes to the association betwee

The influence of the sintering temperature on the mechanical properties of cBN-based ceramic composites with binders in form of vanadium compounds is investigated by methods of physical material science. Two compositions are selected for the study cBN–VC–Al and cBN–VN–Al with 60% vol. of cBN. Samples are obtained by high pressure high temperature sintering (HPHT) in toroid type apparatus with cent

Antalet subventionerade jobb har växt samtidigt som andelen utrikes födda bidragsanställda ökat och andelen funktionsnedsatta minskat. Anställningsbidragen är särskilt frekventa i handels-, restaurang-, städ- och bemanningsbranscherna. I föreliggande studie har samtliga nya anställningsbidrag 2016 i de fyra branscherna i Helsingborg undersökts. En tydlig etnisk segmentering påvisas genom att en beThe number of persons in Sweden with subsidized jobs has grown. At the same time, the share of foreign-born with subsidized jobs has increased, while the share of disabled has declined. The subsidized jobs are most common in the retail, restaurant, cleaning and staffing sectors. The present study investigates all new subsidized jobs in 2016 in these sectors in Helsingborg. The study found clear si

In particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting tooIn particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting too