Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocann

Purpose: To investigate the potential of functional magnetic resonance imaging (fMRI) at 3T as a clinical tool in the preoperative evaluation of patients with intracranial tumors. High magnetic field strength such as 3T is of benefit for fMRI because signal-to-noise ratio and sensitivity to susceptibility changes are field-strength-dependent. Material and Methods: Twenty patients with tumors clos

A series of field studies at cold workplaces were initiated. This paper deals with the study at a telecommunication company and the main attention is paid to the thermal responses of the feet and footwear performance. The study was carried out in February. Eight male workers were the subjects. They were selected among volunteers who carried out various jobs on high masts on four different days. Th

In companies that constantly develop new software releases for large markets, there continually arrive new requirements, written in natural language that may affect the development work. Before any decision is made about the requirements, these must be analysed and understood, and related to the current set of implemented and queued requirements. This task is time-consuming owing to the high inflo

En produkts livscykel kan sällan förläggas till en plats eller ett land. Många produkter har helt eller delar av sitt ursprung i andra länder eller till och med världsdelar. Produktkedjan blir på det sättet mer eller mindre internationell i sina olika faser, vilket leder till konsekvensen att andra länders, EU:s eller andra överstatliga organs produktpolitik får betydelse för produkter som produce

Autooxidation of five polyphenols representing range of different hydrophobicities (catechin gallate (CG), (-) catechin((-)C), epicatechin (EC), epigallocatechin gallate (EGCG) and epigallocatechin (EGC)) in three different aqueous solutions: molecular solution, micellar solution (Tween-20) and liposomal dispersion (soybean lecithin) was monitored by HPLC. The rate of oxidation of the five polyphe

The reactions between galena and synthetic lead(II) sulphide powders, and potassium alkylxanthates have been studied in aqueous, acetone and acetonitrile solutions. Acetone and acetonitrile have been used since potassium and lead(II) alkylxanthates are soluble in these solvents. Qualitative analysis of the alkylxanthate species present on the surfaces of galena and synthetic lead(II) sulphide afte

Detta arbete behandlar tillväxten hos enkelarmerade betongkonstruktioners bärförmåga, speciellt under vinter fram till formgivning. Arbetet är uppdelat i 3 delar. I den första studeras betongens hållfasthetstillväxt vid olika härdningstemperaturer. I den andra delen bestäms brottlasten hos 30 betongbalkar och 6 betongväggar. I den tredje delen beräknas temperaturutvecklingen hos betongbalkar.

The repressor activator protein 1 (RAP1) plays a role in telomere structure and function inS. cerevisiae. Here, the RAP1 homologue was identified and cloned from the budding yeast Saccharomyces castellii (scasRAP1). The scasRAP1 gene encodes a protein of 826 amino acids and shares an overall high degree of similarity with the S. cerevisiae RAP1 (scerRAP1). We demonstrate that the scasRAP1 is able

Tandemly repeated 340 bp sequences, TA repeats, are present in seven of the eight pairs of chromosome ends in Chironomus pallidivittatus, being absent from the telocentric left end of chromosome four. We have previously shown that the family of TA repeats consists of four main subfamilies. One subfamily is composed of a master unit and the other three contain derived units, each of which has a sma

High plasma levels of VLDL are associated with increased risk for atherosclerosis. Here we show that VLDL (75 to 150 microg/mL) activates nuclear factor-kappaB (NF-kappaB), a transcription factor known to play a key role in regulation of inflammation. Oxidation of VLDL reduced its capacity to activate NF-kappaB in vitro, whereas free fatty acids such as linoleic and oleic acid activated NF-kappaB

Inhalation of airborne microorganisms and their toxic components and products may induce a wide spectrum of acute and chronic airway manifestations. The study describes important capabilities of chemical marker analysis in defining human exposure to microorganisms in indoor environments. An integrated procedure is presented where gas chromatography - ion trap tandem mass spectrometry is used to de

This paper gives an overview of the cadmium (Cd) situation in agricultural systems and human exposure in Sweden. Cadmium levels in agricultural soils (the plow layer) increase by 0.03% to 0.05% per year. Feed can give substantial contributions of Cd to local agricultural systems. Effects on human kidney function are indicated by some measurements already at today's exposure levels. If food product

A method with low MDL (minimum detection limit) was developed for analysis of carbon (C), nitrogen (N) and oxygen (O) in aerosol samples collected on an organic backing. An accelerator-produced beam of protons interacting with the sample and the detection of elastically scattered protons (PESA; particle elastic scattering analysis) and emitted X-rays (PIXE; particle-induced X-ray emission) were th

In the reactione + e – rarrW + W – rarr ( $$q_1 ar q_2 $$ ) ( $$Q_1 ar Q_2 $$ ) we expect that normally the colour singlet systems ( $$q_1 ar q_2 $$ ) and ( $$Q_1 ar Q_2 $$ ) hadronize independently into two hadron chains or strings. However also the pairs ( $$q_1 ar Q_2 $$ ) and ( $$Q_1 ar q_2 $$ ) form colour singlets with probability 1/N c 2 =1/9. This probability could be further enhanced by g