Objectives. The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important mediators of inflammation and connective tissue remodelling. The aim of this study was to evaluate if single nucleotide polymorphisms (SNPs) of ALOX5AP confer risk of SSc and/ or SSc-related organ involvement. Methods. Seven SNPs of ALOX5AP (rs17222814, rs17216473

Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1

Reduced pancreatic b-cell function or mass is the critical problem in developing diabetes. Insulin release from b-cells depends on Ca2+ influx through high voltage- gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs aremultisubunit protein complexes composed of a pore-forming a1 and auxiliar

Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were

We have previously reported that once-weekly albiglutide was noninferior to thrice-daily lispro for glycemic lowering, with decreased weight and risk of hypoglycemia, in patients inadequately controlled on basal insulin over 26 weeks. Findings after 52 weeks reveal similar responses to albiglutide as an add-on to insulin glargine.

Land surface phenology is frequently derived from remotely sensed data. However, over regions with seasonal snow cover, remotely-sensed land surface phenology may be dominated by snow seasonality, rather than showing true plant phenology. Overlooking snow influences may lead to inaccurate plant phenology estimation, and consequently to misinterpretation of climate-vegetation interactions. To addre

The class of information set decoding algorithms is the best known way of decoding general codes, i.e. codes that admit no special structure, in the Hamming metric. Stern's algorithm is the origin of the most efficient algorithms in this class. In this paper we consider the same decoding problem but for a channel with soft information. We give a version of Stern's algorithm for a channel with soft

Metaphorical phrases appear frequently in practitioner and academic texts on internal branding and depict employees as ‘brand ambassadors’ who ‘embody the brand’ and ultimately turn into ‘living brands’. In this article, I examine how these metaphorical phrases rhetorically construct the concept of internal branding and thereby also impact our thoughts on organizations, employees and their relatio

NTRU is a public-key cryptosystem, where the underlying mathematical problem is currently safe against large-scale quantum computer attacks. The system is not as well investigated, as for example RSA, and the company behind NTRU has created the NTRU Challenges, to remedy this. These challenges consist of 27 different public keys of increasing size, where the task in each challenge is to calculate

Objectives: This paper estimates the effect of tertiary education eligibility on crime in Sweden. The hypothesis tested is that continuing to higher education decreases crime rates since it allows young people to escape inactivity and idleness, which are known to trigger crime. However, to qualify for tertiary education, individuals have to meet the eligibility requirements in upper-secondary scho

A ripe strawberry looks red to our eyes in sunlight and in the green light of a forest, although the spectrum of light reflected from its surface differs dramatically. This is caused by two effects: colour constancy and our ability to learn relative colour cues - the ripe strawberry remains relatively 'redder' than an unripe green strawberry. While colour constancy - the ability to recognize colou

Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were i

The hydrogen bond (H bond) is one of the most important interactions that form the foundation of secondary and tertiary protein structure. Beyond holding protein structures together, H bonds are also intimately involved in solvent coordination, ligand binding, and enzyme catalysis. The H bond by definition involves the light atom, H, and it is very difficult to study directly, especially with X-ra

Mechanical behavior of the shear connections has a significant influence on both the load-carrying capacity and the bending stiffness of timber-concrete composite (TCC) beams. All the studies reported so far have concentrated on the performance of TCC connections in mature concrete. The performance of shear connections for TCC beams at early concrete ages, however, has not been investigated yet. T

The excellent performance of metal foams is well-recognized in the thermal and energy fields. This paper presents an investigation on the convective heat transfer and thermal performance of microchannel heat sinks with different structures of metal foams, such as Y-shaped, metal foam attached to fins, combined metal foams. The inlet Reynolds number is ranging from 170 to 554 and the porosity of th

In the current study, the effects of the nonlocally generated long sea surface waves (swells) on the power production of a 2 × 2 wind farm are investigated by using large-eddy simulations (LES) and actuator-line method (ALM). The short sea waves are modeled as a roughness height, while the wave-induced stress accounting for swell effects is added as an external source term to the momentum equation

The EU Commission highlights evaluations as important for improving common policies. But do evaluations actually contribute? This paper examines whether this has been the case for the EU Rural Development Programmes (RDPs). We investigate 1) to what extent evaluations have influenced the design of national programmes and 2) if they have affected the Rural Development Regulation on which national p

In Torfs et al. (2017) a new unified framework to model settling tanks in water resource recovery facilities was proposed providing a set of partial differential equations (PDEs) modelling different settling unit processes in wastewater treatment such as primary and secondary settling tanks (PSTs and SSTs). The extension to a multi-class framework to deal with the distributed properties of the set

An algorithm for high-performance path tracking for robot manipulators in the presence of model uncertainties and actuator constraints is presented. The path to be tracked is assumed given, and the nominal trajectories are computed using, for example, well-known algorithms for time-optimal path tracking. For online path tracking, the nominal, feedforward trajectories are combined with feedback in