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Det ideologiska landskapet

The present work is one of nine parts making up the archaeological project The Öresund Fixed Link. The book begins with an account of all the features and artefacts that are considered to have belonged to the ideological sphere within the project. The focus is on two sites, one located on the coast, the other in the outer hummocky landscape. As regards remains on the coast, this work concentrates

Evidence-based recommendations or "Show me the patients selected and I will tell you the results"

Modern treatment decision making in medicine is recommended to be evidence based. In order to have a high grade of evidence, the studies should have sufficient power, be randomized and double blinded. Moreover, the evaluation parameters should be solid and reproducible. While there is a lot focus on primary study design much less is focused on patient eligibility and to what extent the patients in

Mode of delivery in breech presentation at term: increased neonatal morbidity with vaginal delivery

OBJECTIVE: To compare the neonatal outcome in planned vaginal delivery and planned cesarean section in term singleton pregnancies with breech presentation in a Scandinavian clinic with a high rate of vaginal breech delivery. METHODS: A retrospective study including 1050 term singleton breech pregnancies delivered at a Swedish tertiary referral center during 1988 to 2000. For 699 patients (67%) a v

Deprenyl: from chemical synthesis to neuroprotection.

During the last decades (-)-deprenyl has become the golden standard of MAO-B inhibitors. It possesses dopamine potentiating and antioxidant properties; however, its effects cannot be explained solely by the enzyme inhibitory action. (-)-Deprenyl prevents the toxicity of certain selective neurotoxins and recently it was demonstrated to increase cell-cell adhesion as well. The complexity of its phar

Intraplaque haemorrhage at carotid artery surgery--a predictor of cardiovascular mortality

OBJECTIVE. To ascertain whether carotid intraplaque haemorrhage (IH) in patients undergoing carotid artery surgery is a predictor of increased cardiac mortality over a 5.5 year follow-up. DESIGN AND SUBJECTS. Carotid artery plaques were obtained at surgery from 47 consecutive patients (41 men, six women), median age 67 (range 48-81) years, with symptoms of carotid transient ischaemic attacks (TIAs

Human kininogens interact with M protein, a bacterial surface protein and virulence determinant.

Streptococcus pyogenes, the most significant streptococcal species in clinical medicine, expresses surface proteins with affinity for several human plasma proteins. Here we report that kininogens, the precursors to the vasoactive kinins, bind to the surface of S. pyogenes. M protein, a surface molecule and a major virulence factor-in these bacteria, occurs in > 80 different serotypes. Among 49 str

Chromosomal aberrations in benign and malignant Bilharzia-associated bladder lesions analyzed by comparative genomic hybridization.

BACKGROUND: Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance our understanding of the pathogenic mechanisms of the disease but, in contrast to nonbilharzia bladder cancer, BAC has rarely been the object of such scrutiny. In the present study, we aimed t

Introducing intellectual potential

Intellectual capital has gained increasing attention concerning both research and more practically oriented applications during the past five years. Intellectual Capital and other knowledge management tools are topics that have emerged in the light of a broader trend of redirecting the foundation of competitive advantage from the company’s tangible assets to its intangibles such as knowledge base,

A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins.

A disaccharide scaffold based on galabiose (Gal1–4Gal) was synthesized. Four different acceptors were evaluated in the -galactosylation and a relationship between the nucleophilicity, yield, and /-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2′ and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds b

The importance of terrestrial carbon in plankton food webs

Allochthonous substances, i.e. produced in terrestrial ecosystems, are known to fuel bacterial production in humic lakes. I observed that allochthonous carbon subsidizes bacteria even at high levels of phytoplankton biomass. In line with that, my results also show that dissolved organic carbon is largely constituted of terrestrial substances irrespective of lake characteristics. Since bacteria co

Accelerator mass spectrometry

Accelerator mass spectrometry (AMS) is a world-wide spread technique and nearly 50 AMS laboratories exist today. The most widely spread application of AMS is for radiocarbon dating and an estimated total of nearly 100000 14C samples are measured per year. Other isotopes used are 10Be, 26Al, 36Cl, 41Ca, 129I. The number of these measured per year is estimated to be 10% of the number of 14C samples

Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin