Alzheimer’s disease (AD) is the most common cause of dementia, costing about 1% of the global economy. Failures ofclinical trials targeting amyloid-βprotein (Aβ), a key trigger of AD, have been explained by drug inefficiency regardlessof the mechanisms of amyloid neurotoxicity, which are very difficult to address by available technologies. Here, wecombine two imaging modalities that stand at oppos

Recent studies indicate a crucial role for neuronal glycogen storage and degradation in memory formation. We have previously identified alpha-amylase (α-amylase), a glycogen degradation enzyme, located within synaptic-like structures in CA1 pyramidal neurons and shown that individuals with a high copy number variation of α-amylase perform better on the episodic memory test. We reported that neuron

Aggregation of α-synuclein is associated with neurodegeneration and a hallmark pathology in synucleinopathies. These aggregates are thought to function as prion-like particles where the conformation of misfolded α-synuclein determines the traits of the induced pathology, similar to prion diseases. Still, little is known about the molecular targets facilitating the conformation-specific biological

Sweden has set ambitious goals concerning future sustainable cities. Solar energy plays a vital role in this transformation, since it directly relates to our health and well-being, on-site renewable energy production, economic activity, and social interaction. Therefore, prioritizing solar access already in the urban design phase is important to create equal possibilities for everyone living and w

Light stability of different spray dried microencapsulated powders containing the natural colorant bixin was evaluated for 30 days. The encapsulating materials evaluated were sucrose, maltodextrin, and mixtures including gum arabic and pectin as encapsulation enhancers. The photostability of two sets of encapsulated material was compared: one containing purified bixin, and one being an annatto ext

Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where

This book offers insights on politics and ethics of representation that are relevant to researchers concerned with struggles for justice. It takes moments of discomfort in the qualitative research process as important sites of knowledge for exploring representational practices in critical research.The Politics and Ethics of Representation in Qualitative Research draws on experiences from research

This chapter highlights the importance of collective conversations regarding how to navigate the complexity of positions, roles, stakes, interests and feelings that most researchers experience. The author explores a conversational format as a way of writing about affective reflexivity. The chapter departs in a PhD project focusing on the lived experiences of variations of sex characteristics, in o

While Africa is one of the most promising continents in the world, it is facing mounting challenges to sustainable development in terms of disaster risk, climate change, environmental degradation and demographic and socioeconomic processes. Societies are thus increasingly conceived as having to be resilient to safeguard what they value over time. However, for resilience to have any practical meani

When measuring inequality using conventional inequality measures, ethical assumptions about distributional preferences are often implicitly made. In this paper, we ask whether the ethical assumptions underlying the concentration index for income-related health inequality and the Gini index for income inequality are supported in a representative sample of the Swedish population using an internet-ba

OBJECTIVES: To examine physical activity level prior to pregnancy, during pregnancy and postpartum and investigate the association with depressive symptoms postpartum among women in Sweden.STUDY DESIGN: Retrospective observational study including 532 women on self-assessment of physical activity level before pregnancy, during pregnancy and postpartum, depressive symptoms postpartum as well as stre

Study regionThis study focuses on the twelfth largest lake in Sweden, Lake Bolmen and its catchment.Study focusDuring the last decades the process of brownification has resulted in water with browner color, affecting water quality and ecosystems. The occurrence of brownification and its governing factors, especially with regard to the interaction with the environment, is not yet fully understood.

Composition and functioning of arctic soil fungal communities may alter rapidly due to the ongoing trends of warmer temperatures, shifts in nutrient availability and shrub encroachment. In addition, the communities may also be intrinsically shaped by heavy grazing, which may locally induce an ecosystem change that couples with increased soil temperature and nutrients and where shrub encroachment i

This qualitative theological study seeks to shed light on pentecostal theology and spirituality through an investigation of worship as it is practiced in two urban pentecostal-charismatic churches in Nairobi, Kenya. The empirical data serve as a springboard for theological construction and interpretation from a pentecostal perspective. In contemporary charismatic liturgy, the first section of the

The national child helpline in India received a record number of calls during the country’s first COVID-19 lockdown in 2020. Its ability to provide a safety net for children’s protection rights can be an inspiration for other countries.

This article shows that women’s formal political citizenship is intertwined with the right to the city. Using Carol Bacchi’s ‘What’s the Problem Represented to be’ approach, we study how female municipal councillors argued for more public toilets in Sweden's three largest cities. In their motions, the lack of public conveniences was mainly related to a binary discourse of gender, and arguments ref

As a recent literature has demonstrated, men and women differ in their willingness to sort into competitive environments. In particular, men are more willing than women to compete. We investigate whether it is possible to reduce the gender gap in willingness to compete through an information intervention that informs participants of the gap and advises them about the potential earnings implication